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. 2017 Mar 20;13(5):2169–2176. doi: 10.3892/etm.2017.4239

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Transcriptional regulation of COX-2 and iNOS in Leydig cells. Gene expression of (A) COX-2 and (B) iNOS was examined by reverse-transcription quantitative polymerase chain reaction analysis 12 h after the indicated treatments. LPS alone significantly increased the expression of COX-2 and iNOS, which was inhibited by roscovitine, while COX-2 mRNA levels were still higher than those in the control and DMSO groups. *P<0.05; **P<0.01. Groups: Control, injected with saline; case, injected with roscovitine (5 mg/kg) dissolved in DMSO followed by injection of 5 mg/kg LPS in saline; LPS, injected with LPS only; DMSO, injected with DMSO only; LPS, lipopolysaccharide; DMSO, dimethyl sulfoxide; COX, cyclooxygenase; iNOS, inducible nitric oxide synthase.