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Effects AMPK inhibitor on the effect of roscovitine in Leydig cells in vitro. After stimulation with and TNF-α, AMPK inhibitor (Compound C) reversed the inhibitory effect of roscovitine and the expression levels of the proinflammatory cytokine COX-2 at (A and B) the protein level and (C) at the mRNA level. *P<0.05; **P<0.01; ***P<0.001. AMPK, adenosine monophosphate-activated protein kinase; TNF, tumor necrosis factor; COX, cyclooxygenase.
