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. 2017 Feb 27;157(2):291–304. doi: 10.1093/toxsci/kfx045

TABLE 2.

Number of “Meta-Genes” and Enriched Gene Sets in Experimental Subgroups and Number of Contrasts and Studies Contributing to the Subgroup

Category Group Genes
Gene sets
Number of Contrasts Number of Studies
Up Down Up Down
Time Early 164 413 75 62 14 6
Middle 177 209 4 7 15 7
Late 12 12 0 0 21 8

Mode of action Reactive 28 15 5 1 6 5
Endocrine 126 249 0 1 13 6
Neuroactive 120 168 4 32 7 3

Concentration No effect 11 14 2 0 16 5
LOEC 411 531 0 21 15 5
EC 151 327 11 35 21 9
All All 4 7 17 1 45 17