Table 3.

Indices of Insulin Sensitivity, Insulin Secretion, and Disposition Index at Baseline and After 8 and 12 Weeks of Dietary Intervention in the Study Groups

		Study Groups			MUFA vs Control P values	Fiber vs Control P Values
		MUFA (n = 15)	Fiber (n = 15)	Control (n = 13)
Siliver (10−4 dL/kg/min per µU/mL)	Baseline	6.1 ± 4.0	5.8 ± 3.0	6.4 ± 3.7
	8	4.7 ± 2.7	6.1 ± 5.1	9.9 ± 8.9	0.16	0.59
	12	10.0 ± 9.4a	7.2 ± 5.6	6.4 ± 5.5	0.39	0.72
Si* (10−4 dL/kg/min per µU/mL)	Baseline	5.7 ± 7.0	5.3 ± 8.1	4.1 ± 3.4
	8	4.4 ± 2.7	6.0 ± 6.8	4.3 ± 3.1	0.98	0.52
	12	9.7 ± 11.3	7.8 ± 14.8	7.4 ± 11.0	0.61	0.96
Sitotal (10−4 dL/kg/min per µU/mL)	Baseline	11.8 ± 9.3	11.0 ± 9.4	10.5 ± 6.3
	8	9.2 ± 3.7	12.1 ± 11.1	14.2 ± 11.1	0.22	0.81
	12	19.7 ± 18.3a	15.0 ± 17.6	13.7 ± 16.2	0.63	0.98
Phibasal (10−9 min−1)	Baseline	9.4 ± 2.2	9.9 ± 1.7	12.2 ± 6.0
	8	10.6 ± 2.3	9.9 ± 2.6	11.8 ± 5.7	0.02	0.65
	12	9.6 ± 3.0	9.4 ± 2.0	12.1 ± 6.0	0.75	0.46
Phitotal (10−9 min−1)	Baseline	63.8 ± 34.6	61.0 ± 13.4	61.8 ± 27.1
	8	67.3 ± 27.5	57.8 ± 14.5	60.8 ± 23.6	0.30	0.59
	12	58.0 ± 18.7	56.4 ± 12.7	68.2 ± 35.4	0.20	0.11
DI total (10−14 dL/kg/min2 per pmol/L)	Baseline	1394 ± 1497	1143 ± 1047	935 ± 488
	8	1384 ± 993	1124 ± 1124	960 ± 508	0.38	0.75
	12	2026 ± 2215	1532 ± 2153	1024 ± 809	0.19	0.48

Data are expressed as mean ± SD or as otherwise indicated. Estimate of difference between treatment group and control adjusting for baseline (P value). There were no statistical changes from baseline to week 12 observed in these indices for the three groups.

Abbreviations: DI total, total disposition index; Phi_basal, basal insulin secretion; Phi_total, total insulin secretion; Si*, peripheral insulin sensitivity; Si_liver, hepatic insulin sensitivity; Si_total, total insulin sensitivity.

^aP < 0.05 vs 8 weeks.