Table 1.
Baseline Characteristics
| Parameter | Children (≤12 Years Old; n = 19) | Adolescents (>12 and <18 Years Old; n = 34) | All Pediatric Patients <18 Years Old (N = 53) |
|---|---|---|---|
| Demographics | |||
| Female sex, n (%) | 13 (68) | 28 (82) | 41 (77) |
| Age, y | 8.0 ± 3.5 | 15.5 ± 1.8 | 12.8 ± 4.4 |
| Lipodystrophy type, n (%): | |||
| Acquired generalized lipodystrophy | 5 (26) | 3 (9) | 8 (15) |
| Congenital generalized lipodystrophy | 10 (53) | 22 (65) | 32 (60) |
| Familial partial lipodystrophy | 1 (5) | 7 (21) | 8 (15) |
| Atypical progeria | 3 (16) | 2 (6) | 5 (9) |
| Metabolic parameters | |||
| Fasting leptin, median (25th,75th percentile), ng/mLa | 1.0 (0.5, 1.4) | 1.2 (0.8, 3.1) | 1.1 (0.8, 2.5) |
| Triglycerides, median (25th,75th percentile), mg/dLa | 228 (149, 374) | 556 (254, 2727) | 374 (190, 1065) |
| HDL, mg/dL | 29 ± 11 | 28 ± 8.3 | 29 ± 9.4 |
| LDL, mg/dLa | 74 ± 34 | 115 ± 56 | 96 ± 51 |
| Glucose, mg/dLa | 115 ± 43 | 210 ± 78 | 176 ± 81 |
| C-peptide, median (25th,75th percentile), ng/mLa | 7.0 (5.5, 8.9) | 4.4, (2.8, 6.2) | 5.7 (3.3, 7.3) |
| Hemoglobin A1c, %a | 6.1 ± 1.5 | 9.6 ± 1.9 | 8.3 ± 2.4 |
| ALT, median (25th,75th percentile), U/L | 90 (47, 225) | 65 (39, 102) | 73 (45, 126) |
| AST, median (25th,75th percentile), U/L | 64 (39, 126) | 52 (28, 69) | 51 (29, 90) |
All values are mean ± SD unless otherwise stated.
a
P < 0.05 for children vs adolescents.