Table 2.

Pubertal Status Prior to and During Metreleptin Treatment

Pubertal Category	Prior to Metreleptin	Receiving Metreleptin
Precocious puberty	76, 31M, 48M	67,a 76b
Normal prepubertal	30, 59, 65, 66, 67, 68M, 69, 84, 50M	65, 66, 69, 84, 68M,
Normal in puberty	13, 27, 33, 43, 44, 60, 62, 77M, 82, 94, 95, 99, 108M	10, 30, 41, 59, 62, 70, 34M, 48M, 77M, 79M, 108M
Normal puberty complete	1,c 2, 4, 5, 22, 40, 42, 53, 75, 78, 81, 83, 88	1,c 2, 4, 5, 13, 22, 27, 33, 37,40, 42, 44, 49, 53, 75, 60, 64, 78, 81, 83, 88, 93, 94, 95, 99, 101, 24M, 31M, 50M, 54M
Delayed puberty	9, 24M, 49, 64, 93	9, 43d
No data	10, 37, 41, 45, 70, 101, 79M, 11M, 28M, 34M, 54M	45, 82, 11M, 28M

Each patient’s study number is listed in the appropriate category before and during metreleptin treatment. All available data during metreleptin treatment (duration, ≤15 years) were analyzed.

Abbreviation: M, male patient.

^aAccelerated progression of puberty while receiving metreleptin treatment: Tanner V at age 10.9 years.

^bStarted gonadotropin-releasing hormone agonist after initiating metreleptin treatment.

^cMammary aplasia before and after leptin but menstruating and otherwise pubertal.

^dTanner III at initiation of metreleptin (age, 13.6 years) and Tanner III at last follow-up (age, 18.9 years).