Fig 7. Schematic representation of the initial steps of outside-in signaling through α_IIbβ₃.

Inactive α_IIbβ₃ in resting platelets complexed with JAM-A (left). Initial steps of outside-in signaling initiated by Fg binding to α_IIbβ₃ prior to the association of CIB1 leading to filopodia formation (middle). Signaling complex recruited by CIB1 to the α_IIb tail leading to Src activation and platelet spreading (right).