Table 1.

Demographic, clinical and laboratory details of 14 patients with GAS necrotising fasciitis

No	Age/Gender/Aboriginal/Year	Co-morbidities	Prior lesions	Systolic BP at presenttion (mmHg)	Creatinine (μmol/L) (NR 50–100)	Blood culture	emmST a	STSSb
1	45/F/Y/2001	Alcohol excess	Right knee abrasion	85	810	Neg	new emmST	Y
2	50/F/Y/1994	Rheumatoid arthritis	Nil	100	352	Pos	emm56	N
3	47/F/Y/2000	Hemodialysis, Hypertension	Nil	85	739	Pos	emmST3757	Y
4	38/F/Y/2001	Type 2 diabetes, Hemodialysis, Cryptococcal pneumonitis	Buttock ulcer	60	408	Pos	no sequence	Y
5	61/M/N/2001	Rheumatoid arthritis, Corticosteroid therapy, Splenectomy	Vasculitic leg ulcer	70	249	Pos	emm3.2	Y
6	60/M/N/2001	Rheumatoid arthritis, Methotrexate therapy, Pulmonary fibrosis	Leg ulcer	90	237	Neg	emm70	Y
7	27/M/N/1996	Alcohol excess	Nil	70	172	Neg	emm58	Y
8	34/F/Y/1996	SLE, Anti-Phospholipid syndrome, Corticosteroids, Renal impairment	Left thigh skin sore	100	329	Pos	emm69	N
9	44/M/Y/2000	Type 2 diabetes, Alcohol excess, Renal impairment	Wound from catfish barb	90	271	Neg	emm49.3	Y
10	27/F/N/1999	Nil	Nil	90	77	Neg	emm104	N
11	32/F/N/1999	Nil	Buttock excoriation post-cycling	100	177	Neg	emm1	N
12	59/F/N/1999	Nil	Nil	90	118	Neg	emm22	Y
13	50/M/Y/1997	Alcohol excess, Cirrhosis	Leg ulceration	100	112	Pos	emm4	N
14	61/M/N/2001	Alcohol excess, Hypertension, Gout	Ulcerated gouty tophus	90	659	Pos	emm3	Y
No	WCC/Lymphc (×109/L)	Albumin (g/L) (NR 35–45)	Infection site	Time to surgery after presentation	Operation performed	Antibiotic therapy	Myo-necrosis	Died
1	5.7/0.2	21	Right leg	4 days	Debridement, Fasciotomy	Meropenem, Clindamycin	Yes	Yes
2	5.2/0.5	22	Right arm	6 days	Fasciotomy	Penicillin	Yes	Yes
3	9.6/0.3	33	Right breast/Chest wall	5 days	Debridement	Penicillin	No	Yes
4	9.3/0.4	34	Left leg/Abdominal wall	2 days	Debridement	Penicillin, Clindamycin	No	Yes
5	36.7/0.7	23	Left leg	1 day	Above knee amputation	Meropenem, Tobramycin, Clindamycin	No	No
6	23.7/0.5	29	Right leg	0 days	Below knee amputation	Cefazolin, Clindamycin	No	No
7	5.2/0.1	25	Right leg	5 days	Debridement	Penicillin, Clindamycin	No	No
8	7.0/0.3	33	Left leg/Abdominal wall	7 days	Debridement	Penicillin, Clindamycin	Yes	No
9	22.8/0.8	11	Right foot	2 days	Above knee amputation	Flucloxacillin, Metronidazole, Gentamicin	Yes	No
10	23.3/1.0	29	Left shoulder/Chest wall	6 days	Debridement	Meropenem, Clindamycin	No	No
11	21.8/0.5	17	Right leg/Buttock/Perineum	2 days	Debridement	Penicillin, Clindamycin	No	No
12	4.8/0.4	18	Left leg/Abdominal wall	2 days	Debridement	Penicillin, Clindamycin	No	No
13	10.5/0.7	21	Left leg	5 days	Debridement	Penicillin, Clindamycin	No	No
14	4.0/0.2	28	Right leg	4 days	Above knee amputation	Penicillin, Clindamycin	No	No

^a Emm sequence type (see methods for details)

^b Streptococcal toxic shock syndrome (see methods for details)

^c WCC-total blood white cell count (normal range <11.0 × 10⁹/L) Lymph-blood lymphocyte count