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. 2017 May 24;12(5):e0178216. doi: 10.1371/journal.pone.0178216

Table 3. Selected markers of muscle damage and metabolic response to exercise before and after each of three bouts of exhaustive treadmill exercise.

Marker Bouts of exhaustive treadmill exercise
1st bout 2nd bout 3rd bout
before after before after before After
CK (U/l) 162±63 (141) 211±112* (179) 267±216 (158) 302±184* (197) 301±131 (299) 348±130* (320)
AST (U/l) 26±7 (25) 35±19 (30) 29±8 (27) 36±17 (29) 32±10 (33) 54±68* (31)
ALT (U/l) 28±8 (26) 33±14 (28) 29±10 (28) 33±12 (31) 32±11 (35) 48±52* (35)
Lactate (mmol/l) 1.7±0.8 (2.1) 8.9±4.6* (8.0) 1.4±0.7 (1.2) 8.8±5.0* (9.9) 1.6±0.5 (1.5) 8.0±4.5* (7.6)
Creatinine (μmol/l) 84.8±11.6 (81.0) 116.0±6.8* (112.1) 84.3±10.0 (83.2) 113.5±11.1* (106.5) 85.8±13.8 (80.4) 105.9±12.6* (94.1)
Urea (mmol/l) 5.8±1.2 (5.6) 6.4±1.5* (5.8) 5.7±1.1 (5.7) 6.4±1.4 (5.7) 6.1±1.7 (5.5) 6.7±1.7 (5.5)
Glucose (mmol/l) 5.2±0.8 (5.2) 6.8±1.8* (6.1) 5.9±1.1 (5.6) 6.9±1.9 (5.9) 5.1±1.0 (5.1) 6.3±1.8
(5.6)
CRP [mg/L] 0.99±0.60 (0.80) 1.53±1.28* (1.17) 1.29±1.10 (1.00) 1.31±1.29 (0.71) 1.73±1.76 (1.00) 1.92±1.91 (1.04)

CK–creatine kinase, AST–asparate aminotransferase, ALT–alanine aminotransferase, CRP–C-reactive protein. Results are expressed as mean ± standard deviation (and median in parentheses). Other details as for Table 1.

* vs corresponding value before the bout, p<0.05.

† vs corresponding values before the first and the second bout, p<0.05.