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. 2017 Apr 12;60(9):4002–4022. doi: 10.1021/acs.jmedchem.7b00306

Scheme 1. General Route for the Synthesis of 1,3,6-Trimethylbenzimidazolone-Substituted Naphthalimides.

Scheme 1

a) 1,8-naphtalic substituted anhydrids, CH3COOH, rfx; b) amine, potassium carbonate, DMSO, 110 °C; c) amine, cesium carbonate, tris(dibenzylideneacetone)dipalladium, Xantphos, toluene, 60 °C d) alkyl-alcohol, Et3N, bis(triphenylphosphine)palladium(II) chloride, CuI, THF, 65 °C; e) H2, Pd/C, EtOAc, rt.