. Author manuscript; available in PMC: 2017 May 24.

Published in final edited form as: Clin Cancer Res. 2016 Jun 23;22(24):6256–6265. doi: 10.1158/1078-0432.CCR-15-2965

Table 2.

Identified mutations from the tissues and quantified D- and L-2HG levels from matched CSF in a combined cohort of 1→3 based on WHO Grade

Grade #	Mutational status (N)	D-2HG range (μmol/L)	L-2HG range (μmol/L)
II	WT (4)	0.13–0.76	0.15–0.86
	mutant (3)	0.35–1.00	0.99–2.94
III	WT (1)	0.1	0.31
	mutant (8)	0.31–109	0.40–4.08
IV	WT (56)	0.1–2.51	0.14–6.14
	mutant (5)	0.50–55	0.45–2.09
Other	WT (7)	0.55–1.14	0.61–3.01
	mutant (0)	N/A	N/A