Table 1.
Effect of Minor Allele on Age of Natural Menopause.
| Gene (SNP ID) | Minor Allele | Reported effect per minor allele (years)a |
SE | P-value |
|---|---|---|---|---|
| EXO1 (rs1635501) | C | −0.164 | 0.027 | 8.46 × 10−10 |
| TLK1 (rs10183486) | T | −0.196 | 0.026 | 2.21 × 10−14 |
| HELQ (rs4693089) | G | 0.228 | 0.025 | 2.38 × 10−19 |
| UIMC1 (rs365132) | T | 0.287 | 0.025 | 9.11 × 10−32 |
| PRIM1 (rs2277339) | G | −0.380 | 0.042 | 2.47 × 10−19 |
| POLG (rs2307449) | G | −0.184 | 0.025 | 3.56 × 10−13 |
| TMEM224 (rs4806660) | C | −0.406 | 0.03 | 8.88 × 10−16 |
| BRSK1 (rs1172822) | T | −0.391 | 0.06 | 6.28 × 10−07 |
| BRSK1 (rs2384687) | C | −0.381 | 0.059 | 1.39 × 10−10 |
| BRSK1 (rs1551562) | G | −0.428 | 0.07 | 1.04 × 10−09 |
| BRSK1 (rs897798) | G | −0.308 | 0.056 | 3.91 × 10−06 |
| MCM8 (rs236114) | A | 0.495 | 0.077 | 9.71 × 10−11 |
| MCM8 (rs16991615) | A | 0.948 | 0.052 | 1.42 × 10−73 |
a
Stolk, Lisette, et al. "Loci at chromosomes 13, 19 and 20 influence age at natural menopause." Nature genetics 41.6 (2009): 645–647. Stolk, Lisette, et al. "Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways." Nature genetics 44.3 (2012): 260–268. Murray, Anna, et al. "Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study."Human molecular genetics 20.1 (2011): 186–192.