Table 1.
Demographic and clinical characteristics of the PD-IC group and PD-MCI groups according to the duration of parkinsonism before MCI diagnosis.
| PD-IC (n = 29) | PD-MCI-SD (n = 20) | PD-MCI-LD (n = 18) | P value§ | Post-hoc analysis | |||
|---|---|---|---|---|---|---|---|
| P † | P ‡ | P ¶ | |||||
| Age, year | 65.5 ± 9.4 | 67.0 ± 8.4 | 69.2 ± 7.4 | 0.373 | 0.824 | 0.339 | 0.719 |
| Age at onset, year | 64.2 ± 9.6 | 66.4 ± 8.4 | 66.4 ± 7.8 | 0.597 | 0.670 | 0.676 | 1.000 |
| Male, n (%) | 12 (41.3) | 6 (30) | 9 (50) | 0.449 | 1.000 | 1.000 | 0.624 |
| Education duration, year | 10.7 ± 4.5 | 10.5 ± 5.5 | 7.8 ± 4.8 | 0.126 | 0.990 | 0.133 | 0.220 |
| Parkinsonism duration prior to MCI, month, median (range) | NA | 6 (2–11) | 25 (12–85) | <0.001 | |||
| UPDRS III | 18.9 ± 8.4 | 20.4 ± 6.7 | 29.0 ± 7.4 | <0.001 | 0.794 | <0.001 | 0.003 |
| K-MMSE | 28.3 ± 1.9 | 26.9 ± 1.9 | 26.2 ± 2.8 | 0.002 | 0.015 | 0.009 | 1.000 |
| BDI | 11.0 ± 9.1 | 12.4 ± 7.1 | 9.7 ± 9.3 | 0.623 | 0.850 | 0.858 | 0.595 |
| Interval between MR scan and NP test, d, median (range) | 1.0 (0–125) | 0 (0–35) | 0 (0–43) | 0.059 | 0.060 | 0.807 | 0.642 |
Abbreviations: BDI = Beck Depression Inventory; K-MMSE = the Korean version of the Mini Mental State Examination; MCI = mild cognitive impairment; n = number; NP test = neuropsychological test; PD-IC = Parkinson’s disease with intact cognition; PD-MCI-SD = Parkinson’s disease with a shorter duration of parkinsonism before mild cognitive impairment diagnosis; PD-MCI-LD = Parkinson’s disease with a longer duration of parkinsonism before mild cognitive impairment diagnosis; UPDRS III = Unified Parkinson’s Disease Rating Scale Part III.
Note.-Unless otherwise indicated, data are means ± standard deviations.
§ P values for comparison among the 3 groups; † P values for comparison between the PD-IC and PD-MCI-SD groups; ‡ P values for comparison between the PD-IC and PD-MCI-LD groups; ¶ P values for comparison between the PD-MCI-SD and PD-MCI-LD groups.