Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 24;7:2353. doi: 10.1038/s41598-017-02564-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Absence of IPS-1 predisposes towards bronchiolitis and airway epithelial cell necroptosis during acute viral infection. (a) TNF-α protein expression in lung. (b) Neutrophil numbers in bronchoalveolar lavage fluid (BALF). (c) AEC sloughing represented as percentage of airway basement membrane. (d) dsDNA expression in BALF. Lung gene expression of (e) Caspase 3, (f) Rip1, (g) Rip3 and (h) MLKL. (i) Left panel: representative micrograph (100x magnification) of cleaved caspase 3 immunostaining. Right panel: Quantification of cleaved caspase 3 expression in AECs. (j) Left panel: representative micrograph (100x magnification) of MLKL immunostaining. Right panel: Quantification of cleaved MLKL expression in AECs. Experiments were performed twice with 6 to 8 mice per group. Vehicle control mice were sacrificed on day 7 of life (i.e. 0 dpi). Data are mean and the standard error of the mean. *^,**^,***^,****Denotes significance between WT and IPS-1^−/− infected mice. ^#,##,###Denotes significance between infected and vehicle IPS-1^−/− mice. Detection limits are denoted by a red dotted line.