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. 2017 May 24;7:2316. doi: 10.1038/s41598-017-02583-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The firing frequency and threshold current of action potential generation are regulated by ET1 and ETBR antagonists. (a) Voltage responses of a representative pyramidal neuron in the BLA to current injections of, from bottom to top, 0, 100, 200, 300, 400, and 500 pA. Different concentrations of ET1 solution were applied. (b) Summary plot of the firing frequency before and after application of 200 pM ET1 (n = 8/group). (c) Summary histogram of the threshold current for action potential before and after application of 200 pM ET1 (n = 8/group). (d) Voltage response of a representative pyramidal neuron in the BLA to current injections of, from bottom to top, 0 to 500 pA, before and after BQ123 treatment. (e) Summary plot of the firing frequency before and after application of 1 nm BQ123 (n = 8/group). (f) Summary histogram of the threshold current for action potential before and after application of 1 nm BQ123 (n = 8/group). (g) Voltage response of a representative pyramidal neuron in the BLA to current injections of, from bottom to top, 0 to 500 pA, before and after BQ788 treatment. (h) Summary plot of the firing frequency before and after application of 2 nM BQ788 (n = 6/group). (i) Summary histogram of the threshold current before and after application of 2 nM BQ788 (n = 6/group). *P < 0.05, two-way ANOVA test with one factor as repeated measure for 4b, 4e and 4 h and Student’s t test for 4c, 4f and 4i.