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. 2017 May 24;7:2371. doi: 10.1038/s41598-017-02490-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Runx2 reversed MMP13 up-regulation induced by DMM surgery. DMM surgery and Sham operation was performed in 12-week-old male Cre-negative and Runx2 ^Agc1CreER KO mice. MMP13 expression was analyzed by IHC assay. Increased MMP13 expression was detected and more MMP13-positive cells were located toward articular surface in Cre-negative control mice 8 and 12-weeks after DMM surgery (MMP13-positive cells: red arrowheads). Deletion of Runx2 significantly down-regulated MMP13 up-regulation induced by DMM (scale bar = 100 μm).