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. 2017 May 24;7:2371. doi: 10.1038/s41598-017-02490-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Runx2 in chondrocytes isolated from early postnatal mice causes decreased expression of genes encoding to matrix degradation enzymes. (a–h) Primary articular chondrocytes were isolated from 4-day-old Runx2 ^Agc1CreER mice (Cre⁺) and Cre-negative control mice (Cre⁻) and treated with 4-hydroxy tamoxifen (1 μM) for 24 hours, followed by real-time PCR assay. Expression of Mmp9, Mmp13, Adamts4, Adamts5, Adamts7 and Adamts12 was significantly reduced in Runx2 deficient chondrocytes (*P < 0.05 and **P < 0.01, Unpaired Student’s t-test; n = 3 mice per group).