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. 2017 May 24;7:2371. doi: 10.1038/s41598-017-02490-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Runx2 in adult articular chondrocytes leads to decreased expression of genes encoding to matrix degradation enzymes. (a–h) Total RNA was extracted from articular chondrocytes isolated from 5-month-old Runx2 ^Agc1CreER KO mice (KO) or Cre-negative control mice (Cre⁻) followed by real-time PCR assay. All these mice were administrated with tamoxifen at the two-months of age and received DMM surgery at 12-week-old. Expression of Mmp9, Mmp13, Adamts4, Adamts5, Adamts7 and Adamts12 was significantly reduced in articular chondrocytes derived from Runx2 ^Agc1CreER KO mice (*P < 0.05 and **P < 0.01, unpaired Student’s t-test; n = 3 mice per group).