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. 2017 May 24;7:2325. doi: 10.1038/s41598-017-02440-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical isolates of DP-rings are susceptible to KDU691. (A) Rings and (B) DP-rings. Data were normalized to (A) DMSO-treated rings and (B) DMSO-treated DP-rings. Measurements were taken by HCI using MitoTracker® Orange at day three for rings and day six for DP-rings. KDU691 was added at a concentration of 1.4 µM. Data are from three biological experiments and two technical replicates each (means ± SEM % growth). Percent growth was measured by HCI using MitoTracker® Orange relative to DMSO.