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. 2017 May 24;7:2390. doi: 10.1038/s41598-017-02549-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Deletion of RDH10 in the entire retina does not affect cone responses. Representative transretinal cone responses from (A) Six3-Cre control, and (B) Six3-Cre Rdh10 ^flox/flox retinas. Red traces: responses to a 1.4 × 10⁴ photons/μm² test flash. (C) Normalized cone intensity-response curves of Six3-Cre control (n = 9, filled symbols) and Six3-Cre Rdh10 ^flox/flox (n = 8, open symbols) retinas. Inset: normalized cone dim flash responses from Six3-Cre control (n = 9, black trace) and Six3-Cre Rdh10 ^flox/flox (n = 8, red trace) retinas. All mice were in Gnat1 ^−/− background to facilitate cone recordings.