Table 1.
Study Population Demographic and Clinical Characteristics at Intensive Care Unit Admission
| ARDS Cases (n = 414) |
||
|---|---|---|
| Variable | Survivor | Nonsurvivor* |
| N |
298 (72.0) |
116 (28.0) |
| APACHE III score | 72.8 ± 21.3† | 91.2 ± 19.9 |
| Age, yr | 55.8 ± 17.5 | 68.0 ± 13.7 |
| Sex | ||
| Male | 191 (64.1) | 71 (61.2) |
| Female | 107 (35.9) | 45 (38.8) |
| Baseline platelet count‡, 103/μl | 216.1 ± 139.3§ | 189.2 ± 158.6 |
| ∆PLT28d‖, 103/μl | 57.5 ± 107.3§ | 85.8 ± 119.9 |
| ∆PLT7d¶, 103/μl | 40.6 ± 101.5** | 76.5 ± 113.8 |
| Ethnicity | ||
| Caucasian | 290 (97.3) | 113 (97.4) |
| African American | 3 (1.0) | 0 (0.0) |
| Hispanic | 2 (0.7) | 2 (1.7) |
| Asian/Pacific Islander | 2 (0.7) | 0 (0.0) |
| Other | 1 (0.3) | 1 (0.9) |
| Physiology | ||
| Heart rate, beats/min | ||
| Lowest†† | 79.6 ± 19.2 | 79.9 ± 17.9 |
| Highest‡‡ | 120.2 ± 22.9 | 120.9 ± 22.1 |
| Respiratory rate, breaths/min | ||
| Lowest†† | 15.7 ± 5.2§ | 16.9 ± 5.6 |
| Highest‡‡ | 30.3 ± 8.9 | 31.8 ± 8.8 |
| Systolic blood pressure, mmHg | ||
| Lowest†† | 81.8 ± 15.9 | 77.1 ± 14.6 |
| Highest‡‡ | 146.8 ± 24.4 | 143.9 ± 21.9 |
| Mean arterial pressure, mmHg | ||
| Lowest†† | 57.9 ± 10.0† | 54.1 ± 8.3 |
| Highest‡‡ | 99.8 ± 16.6 | 96.5 ± 13.9 |
| ABG testing in 24 h after ICU admission | ||
| PaO2, mmHg | 118.0 ± 73.6 | 118.1 ± 73.0 |
| FiO2, mmHg | 0.79 ± 0.23 | 0.80 ± 0.23 |
| P/F ratio | 157.4 ± 87.0 | 156.9 ± 93.3 |
| ARDS predispositions | ||
| Sepsis | 261 (87.6)† | 113 (97.4) |
| Pneumonia | 207 (69.5) | 82 (70.7) |
| Aspiration | 30 (10.1) | 8 (6.9) |
| Multiple transfusion | 25 (8.4) | 8 (6.9) |
| Pulmonary contusion | 12 (4.0) | 1 (0.9) |
| Multiple fractures | 12 (4.0) | 1 (0.9) |
| Complications | ||
| Diabetes mellitus | 57 (19.3) | 27 (23.3) |
| Immune suppression§§ | 21 (7.1) | 14 (12.1) |
| Chronic dialysis or peritoneal dialysis | 25 (8.5) | 12 (10.3) |
| Cirrhosis | 10 (3.4) | 16 (13.8) |
| Hepatic failure with coma or encephalopathy | 9 (3.1) | 8 (6.9) |
| Solid tumor with metastasis | 4 (1.4) | 5 (4.3) |
| Non-Hodgkin’s lymphoma | 0 (0.0) | 2 (1.7) |
Definition of abbreviations: ABG = arterial blood gas; APACHE = Acute Physiology and Chronic Health Evaluation; ARDS = acute respiratory distress syndrome; ICU = intensive care unit; P/F = PaO2/FiO2; ∆PLT = platelet count decline.
Continuous variables are described as mean ± SD and compared by t test or Kruskall-Wallis rank sum test (platelet variables); categorical variables are described as number (%) and compared by Fisher’s exact test.
Patients dead within 28 days after ICU admission.
P < 0.001.
Lowest platelet count at ICU admission.
P < 0.05.
Maximal platelet count decline within 28 days (∆PLT28d) after ICU admission compared with baseline platelet count.
Maximal platelet count decline within 7 days (∆PLT7d) after ICU admission compared with baseline platelet count.
P < 0.01.
Minimal value in first 24 hours of ICU admission.
Maximal value in first 24 hours of ICU admission
Immune suppression within the past 6 months including radiation or chemotherapy with ≥0.3 mg/kg/d prednisone or equivalent.