Table 1.
Baseline Characteristics of the Cohort
| Baseline Characteristics | Full Cohort | Patients Providing Sputum |
|---|---|---|
| N | 433 | 381 |
| Age, yr | 67 (58–74) | 67 (58–74) |
| Sex, % female | 263 (60.7) | 225 (59.1) |
| Body mass index | 25.0 (22.3–28.5) | 25.1 (22.2–28.6) |
| Smoking status, never/ex/current | 266 (61)/151 (34.9)/16 (3.7) | 239 (62.7)/131 (34.4)/11 (2.9) |
| MRC dyspnea score | 2 (1–3) | 2 (1–3) |
| FEV1, L | 1.58 (1.10–2.20) | 1.58 (1.10–2.23) |
| FEV1% predicted | 71.9 (50.0–91.0) | 71.4 (49.4–90.9) |
| FVC, L | 2.45 (1.84–3.21) | 2.41 (1.85–3.19) |
| FVC, % predicted | 83.9 (68.4–99.5) | 83.2 (67.7–98.7) |
| Etiology of bronchiectasis | ||
| Idiopathic | 195 (45.0) | 169 (44.4) |
| Postinfective | 84 (19.4) | 78 (20.5) |
| Previous ABPA | 37 (8.5) | 34 (8.9) |
| Asthma | 15 (3.5) | 14 (3.7) |
| COPD | 22 (5.1) | 19 (5.0) |
| Rheumatoid arthritis | 21 (4.8) | 17 (4.4) |
| Connective tissue disease | 6 (1.4) | 4 (1.0) |
| Inflammatory bowel disease | 11 (2.5) | 11 (2.9) |
| Primary immunodeficiency | 18 (4.2) | 17 (4.5) |
| Previous NTM infection | 7 (1.6) | 4 (1.0) |
| Primary ciliary dyskinesia | 4 (0.9) | 3 (0.8) |
| Alpha-1 antitrypsin deficiency | 2 (0.5) | 1 (0.3) |
| Others | 11 (2.5) | 10 (2.6) |
| Exacerbations per year | 1 (0–3) | 1 (0–3) |
| Previous hospitalization for severe exacerbations | 107 (24.7) | 101 (26.5) |
| St. George’s Respiratory Questionnaire total score | 44.3 (24.6–62.7) | 46.1 (27.3–63.2) |
| Bronchiectatic on CT | 3 (2–4) | 3 (2–4) |
| Reiff score | 3 (2–6) | 3 (2–6) |
| Chronic colonization* | 236 (54.5) | 213 (55.9) |
| H. influenzae | 129 (29.8) | 116 (30.4) |
| P. aeruginosa | 63 (14.5) | 60 (15.7) |
| Moraxella catarrhalis | 51 (11.8) | 49 (12.9) |
| Streptococcus pneumoniae | 25 (5.8) | 23 (6.0) |
| Streptococcus aureus | 34 (7.9) | 30 (7.9) |
| Enterobacteriaceae | 39 (9.0) | 39 (10.2) |
| Bronchiectasis severity index | 6 (4–10) | 6 (4–11) |
| Mild | 126 (29.1) | 108 (28.3) |
| Moderate | 170 (39.3) | 144 (37.8) |
| Severe | 137 (31.6) | 129 (33.9) |
Definition of abbreviations: ABPA = allergic bronchopulmonary aspergillosis; COPD = chronic obstructive pulmonary disease; CT = computed tomography; MRC = Medical Research Council; NTM = nontuberculous mycobacteria.
Data are presented as median (interquartile range) or n (%).
*
Defined as isolation of a pathogenic microorganism in sputum when clinically stable on two occasions at least 3 months apart in a 12-month period.