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. 2017 May 6;5:97–104. doi: 10.1016/j.omto.2017.05.001

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© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Cytotoxicity of Oncolytic Adenoviral Vectors with Differential E1 Gene Product Regulation in Both Human and Murine Glioma Cell Lines

(A and B) Cells were infected with Ad5PK7-Sur E1 or Ad5RGD-CMV-Δ24 at an MOI of 100 VP/cell for 2 hr in (A) human glioma cell lines (U87 and U251) and non-neoplastic cells (normal human astrocytes and neuronal stem cells) and (B) a murine glioma cell line (GL261-OVA). The virus-containing medium was removed and replaced with fresh medium containing 2% FBS. At time points of 24, 48, 72, and 96 hr, the MTT assay was performed according to the manufacturer’s instructions. Each data point and column is the average of three independent replicates. The mean ± SE is plotted. NHA, normal human astrocyte; ns, not significant; NSC, neuronal stem cell; VP, viral particle.