Figure 1.

MdmX has a conserved flexible linker. (a) Plot showing IUPred disorder prediction of human MdmX. (b) Domain schematic of human MdmX showing position of p53 binding domain (p53BD), the linker, and the WW motif. The residue numbers in the disorder prediction are aligned with the domain schematic. (c) Model showing competition between the WW motif and p53TAD for the p53BD. (d) Histogram showing the distribution of lengths for the flexible linkers of 52 MdmX homologs based on a multiple protein sequence alignment that included 10 primates, 24 other mammals, 4 birds, 1 amphibian, 1 reptile, and 12 fish. The number of species in each bin is shown above the bars.