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. 2017 May 18;17(Suppl 1):55. doi: 10.1186/s12911-017-0449-x

Fig. 1.

Fig. 1

Network Mirroring. PrDN and DrDN are disease networks using protein information and drug information respectively. If we reflect the two networks, it would be easier to identify diseases with different connections. Different connections of disease nodes in two networks indicate that diseases which are similar in PrDN i.e. they share same protein information actually have different drug profiles. Given that diseases with similar bio-molecular characteristics can be treated by similar drugs, there is possibility of drug repositioning between these diseases