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. 2017 Mar 29;6(6):512–523. doi: 10.1016/j.molmet.2017.03.008

Figure 5.

Figure 5

Liver Clock gene therapy partially restores metabolic parameters in Clock mutant mice. A, B: Light:dark phase leptin (A) and acylated (Ac-)ghrelin (B) serum concentrations in WT, MT, and MT-LR mice (means ± SEM (n = 9–11); 2-way ANOVAs with Bonferroni post-test; ***: p < 0.001; Student's t-test; (*): p < 0.05; (***): p < 0.001). C, D: Oil red-O staining of liver sections of WT, MT and MT-LR mice. (C) Representative micrographs; (D) Densitometric analysis (means ± SEM (n = 8); 1-way ANOVA with Bonferroni post-test; ***: p < 0.001). (D) blood glucose levels after intraperitoneal glucose injection in WT, MT, and MT-LR mice (means ± SEM (n = 8); 2-way ANOVA with Bonferroni post-test; *: p < 0.05 vs. WT). Inset shows area-under-the-curve analysis (letters depict significant differences (p < 0.05, 1-way ANOVA)).