TABLE 2.
Noncompartmental analysis of serum pyrazinamide concentrations
| Parametera | Median (range) valueb |
|---|---|
| kel (h−1) | 0.059 (0.039–0.13) |
| t1/2 (h) | 11.7 (5.3–17.6) |
| Tmax (h) | 2.0 (1.7–4) |
| Cmax (μg/ml) | 37.8 (27.1–54.7) |
| AUClast (μg · h/ml) | 246.7 (69.6–353.1) |
| AUC0–∞ (μg · h/ml) | 827.6 (208.5–1,139.7) |
| CL/F (liters/h) | 1.9 (1.4–7.7) |
| V/F (liters) | 36.4 (28.6–58.5) |
a
kel, elimination rate constant; t1/2, half-life; Tmax, time to Cmax; Cmax, maximal serum concentration; AUClast, area under the serum concentration-versus-time curve at the time of the last concentration determination; AUC0–∞, area under the serum concentration-versus-time curve from time zero to infinity; CL, clearance; V, volume of distribution; F, bioavailability (which was assumed to be 1 for purposes of analysis).
b
Data are for 10 patients receiving pyrazinamide.