FIG 3.

Dose-response curves (A) and 24-h AUC/MIC ratio in relation to treatment effect (B) against five select E. coli strains using a neutropenic mouse thigh model. Each symbol represents the mean from four thighs. The horizontal dashed line at 0 represents the burden of organisms in the thighs of mice at the start of therapy. Data points below the line represent killing, and points above the line represent growth. The R² represents the coefficient of determination. The ED₅₀ represents the AUC/MIC ratio associated with 50% of the maximal effect (E_max), and N is the slope of the relationship or the Hill coefficient. The line drawn through the data points is the best-fit line based upon the sigmoid E_max formula.