FIG 5.
The dose-response curves (A) and 24-h AUC/MIC ratio in relation to treatment effect (B) against two select P. aeruginosa strains using a neutropenic mouse thigh model. Each symbol represents the mean from four thighs. The horizontal dashed line at 0 represents the burden of organisms in the thighs of mice at the start of therapy. Data points below the line represent killing, and points above the line represent growth. The R2 represents the coefficient of determination. The ED50 represents the AUC/MIC ratio associated with 50% of the maximal effect (Emax), and N is the slope of the relationship or the Hill coefficient. The line drawn through the data points is the best-fit line based upon the sigmoid Emax formula.