TABLE 2.
In vitro and in vivo efficacy of fosfomycin against E. coli, K. pneumoniae, and P. aeruginosa
| Organism group, strain, and/or parameter | Control growth (log10 CFU/ml) | MIC (mg/liter) | Static dose (mg/kg/24 h) | 24-h static dose AUC/MIC ratio | Static dose time above MIC (%) | 1-log kill dose (mg/kg/24 h) | 24-h 1-log kill AUC/MIC ratio | 1-log kill dose time above MIC (%) |
|---|---|---|---|---|---|---|---|---|
| E. coli | ||||||||
| 145 | 2.31 | 2 | 97.2 | 19.3 | 41.4 | 348 | 27.5 | 51.9 |
| 681 | 2.52 | 16 | 3,305 | 18.9 | 37.7 | NAa | ||
| 6042 | 1.81 | 8 | 491 | 8.5 | 15.0 | 3,572 | 41.6 | 75.9 |
| ATCC 25922 | 2.15 | 1 | 256 | 49.4 | 67.5 | 1,644 | 193 | 100 |
| 1-741-1 | 2.57 | 1 | 86.3 | 22.4 | 31.4 | 1,372 | 133 | 74.8 |
| Mean | 847 | 23.7 | 38.6 | 1,734 | 98.9 | 75.8 | ||
| Median | 256 | 19.3 | 37.7 | 1,508 | 87.5 | 75.3 | ||
| SD | 1,383 | 15.3 | 19.1 | 1,346 | 78.4 | 19.9 | ||
| K. pneumoniae | ||||||||
| 7023 | 1.265 | 16 | 1,122 | 8.61 | 12.8 | NA | ||
| 7068 | 1.8,375 | 8 | 3,707 | 43.6 | 78.0 | NA | ||
| 7040 | 1.25 | 4 | 171 | 11.1 | 26.5 | 652 | 21.5 | 42.6 |
| Mean | 1,667 | 21.1 | 39.1 | |||||
| Median | 1,122 | 11.1 | 26.5 | |||||
| SD | 1,830 | 19.5 | 34.4 | |||||
| Enterobacteriaceae group | ||||||||
| Mean | 1,154 | 22.7 | 38.8 | 1,518 | 83.3 | 69.0 | ||
| Median | 374 | 19.1 | 34.6 | 1,372 | 41.6 | 74.8 | ||
| SD | 1,494 | 15.6 | 23.4 | 1,262 | 76.1 | 22.5 | ||
| P. aeruginosa | ||||||||
| ATCC 27853 | 3.42 | 8 | 692 | 11.3 | 22.5 | 1,004 | 15.6 | 30.9 |
| 9002 | 3.52 | 16 | 3,148 | 17.9 | 35.4 | 6,310 | 40.8 | 76.4 |
a
NA, not achieved.