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. 2017 May 24;61(6):e02402-16. doi: 10.1128/AAC.02402-16

FIG 1.

FIG 1

Bactericidal activities of delamanid (DLM) against replicating and nonreplicating bacilli. (A) Bactericidal activities against replicating cells. One-day-cultured M. bovis BCG Tokyo bacilli were treated with delamanid at 0.0032, 0.016, 0.08, and 0.4 mg/liter, isoniazid (INH) at 0.08, 0.4, and 2 mg/liter, and metronidazole (MTZ) at 10, 50, 250 mg/liter for 7 days. The numbers of CFU per milliliter at the end of treatment were counted. DMSO was used as a control. The number of CFU per milliliter in day 0 culture was used as the initial control. (B) Bactericidal activities against nonreplicating M. bovis BCG Tokyo cells. M. bovis BCG Tokyo was cultured in a modified Wayne model, and nonreplicating bacilli were treated with DLM at 0.016, 0.08, 0.4, 2, and 10 mg/liter; INH at 0.4, 2, and 10 mg/liter; and MTZ at 2, 10, and 50 mg/liter for 7 days. Each value represents the mean of results from triplicate samples ± the standard deviation (SD) from three replicates. Treated groups were compared with the control by Dunnett's test. **, P < 0.01.