TABLE 1.

Plasma levels of agents used for evaluating regimens in guinea pigs

Agenta	Guinea pigsb			Humans
	Dose (mg/kg)	Cmax (mg/liter)	AUCt (mg · h/liter)c	Dose (mg)	Cmax (mg/liter)	AUCt (mg · h/liter)	Reference
DLM	10	0.21	2.32	100 BIDd	0.414e	7.925	18
					(0.4f)
	100	0.53	9.45	200 BID	0.611e	11.837
					(0.588f)
RIF	25	6.76	28.28	450	5.5	29.7	33
INH	25	12.75	28.26	300	4.5	22.9	34
PZA	150	128.95	218.96	1,500	55.5	241	35
LVX	50	12.66	44.49	1,000	15.55	NCg	36
ETO	50	6.33	4.96	500	NC	3.95	37

^aPZA, pyrazinamide; LVX, levofloxacin; ETO, ethionamide.

^bThe doses set up for using the plasma C_max or AUC_t achieved in the guinea pig model are equivalent to those achieved in humans at the clinical dose.

^cAUC_ts for guinea pig results were calculated by the trapezoidal rule up to 24 h.

^dBID, twice daily.

^eMaximum plasma concentration following the first daily dose.

^fMaximum plasma concentration following the second daily dose.

^gNC, not calculated.