TABLE 6.
Results of blood antibacterial activity assay
| Dose (mg/kg) | Pharmacodynamic assay result (μg/ml)a |
||
|---|---|---|---|
| 1 h | 1.5 h | 2 h | |
| 0.1 (n = 3) | NQ | NQ | NQ |
| 0.3 (n = 6) | NQ | NQ | NQ |
| 1 (n = 6) | 0.13 ± 0.05 (6) | NQ | NQ |
| 3 (n = 6) | 0.22 ± 0.10 (6) | NQ | NQ |
| 10 (n = 6) | 0.40 ± 0.13 (6) | 0.15 ± 0.05 (6) | 0.08 ± 0.03 (3) |
a
All data are presented as the mean ± SD concentration (in micrograms per milliliter), and the number of participants is presented in parentheses. NQ, not quantifiable as the value was less than the LLOQ (0.05 μg/ml).