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Tumor-induced bone remodeling, referred pain, and impaired limb use. A, Representative radiographs demonstrating significant bone loss in male and female rats with fractures developing within 12 d after injection. B, C, Time-dependent development of tactile hypersensitivity (B) and impaired limb use (C). *p < 0.05, **p < 0.01, ***p < 0.001 versus presurgery BL. Graphs are mean ± SEM. n = 8.
