Figure 3.

Movement-induced BTP is prevented, but not reversed, by saphenous lidocaine. A, Group comparison of difference scores demonstrating that movement of the tumor-bearing hindlimb 10 min after saphenous saline induced CPA in tumor-bearing rats. *p < 0.05 versus sham saline. Pretreatment with lidocaine 10 min before movement resulted in a significant increase in time spent in the movement-paired chamber. ***p < 0.001 versus sham saline. Neither saline nor lidocaine treatment 10 min before movement altered time spent in the movement-paired chamber in sham rats. n = 7/group. B, Group comparison of difference scores showing that cancer-treated rats demonstrated equivalent decreases in time spent in the movement-paired chamber when treated with saline or lidocaine 10 min after movement. **p < 0.01 versus sham saline, *p < 0.05 versus sham lidocaine. Neither saline nor lidocaine treatment 10 min after movement altered time spent in the movement-paired chamber in sham rats. Graphs are mean ± SEM. n = 5/group sham rats; n = 7/group tumor-bearing rats.