Table 2.

Statistical analysis results for ANOVA

Factor	F(DF1,DF2)	p-value
Two-way ANOVA of tumor-induced tactile hypersensitivity (Figure 1A)
Interaction	F(8,76) = 2.733	p = 0.0015
Time	F(4,76) = 11.23	p < 0.0001
Sex	F(2,19) = 5.46	p < 0.0134
Two-way ANOVA of tumor-induced hindlimb impairment (Figure 1B)
Interaction	F(8,76) = 7.238	p < 0.0001
Time	F(4,76) = 30.23	p < 0.0001
Sex	F(2,19) = 28.21	p < 0.0001
Two-way ANOVA of BTP in morphine-pellet-treated rats (Figure 2B)
Interaction	F(1,23) = 0.3347	p = 0.5685
Tumor	F(1,23) = 31.59	p < 0.0001
Drug	F(1,23) = 0.0409	p = 0.8415
Two-way ANOVA of lidocaine pretreatment on BTP (Figure 3A)
Interaction	F(1,24) = 20.26	p < 0.0001
Tumor	F(1,24) = 2.99	p = 0.0966
Lidocaine	F(1,24) = 26.01	p < 0.0001
Two-way ANOVA of lidocaine posttreatment on BTP (Figure 3B)
Interaction	F(1,18) = 0.1254	p = 0.7273
Tumor	F(1,18) = 19.42	p = 0.0003
Lidocaine	F(1,18) = 0.05562	p = 0.8162
One-way ANOVA of IB4 intensity ratio (Figure 4M)
Treatment	F(2,5) = 6.93	p < 0.036
One-way ANOVA of TRPV1 intensity ratio (Figure 4N)
Treatment	F(2,6) = 20.97	p < 0.002
One-way ANOVA of SP intensity ratio (Figure 4O)
Treatment	F(2,6) = 8.82	p < 0.016
One-way ANOVA of CGRP intensity ratio (Figure 4P)
Treatment	F(2,6) = 5.85	p < 0.039
Two-way ANOVA of Ablation effects on tactile hypersensitivity (Figure 5A)
Interaction	F(2,47) = 2.518	p < 0.0914
IB4 vs TRPV1 ablation	F(2,47) = 29.68	p < 0.0001
Tumor	F(1,47) = 0.2817	p < 0.5981
Two-way ANOVA of ablation effects on BTP (Figure 5B)
Interaction	F(2,54) = 1.12	p = 0.3338
Tumor	F(2,54) = 5.199	p = 0.0086
IB4 vs TRPV1 ablation	F(1,54) = 1.065	p = 0.30368
Two-way ANOVA of ablation effects on bone remodeling (Figure 6B)
Interaction	F(1,21) = 0.6508	p = 0.4289
Drug	F(1,21) = 0.3508	p = 0.2715
IB4 vs TRPV1 ablation	F(1,21) = 0.0005	p = 0.9818