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. 2017 May 17;37(20):5144–5154. doi: 10.1523/JNEUROSCI.3545-16.2017

Figure 5.

Figure 5.

Hyperactivity induced by vestibular failure is independent of age in Tbx1Cre/+;Slc12a2fx/fx mutants. A, Mild mutants become hyperactive between16 and 23 weeks of age. Six weeks severe versus control: p = 0.0065; 8 weeks severe versus mild: p = 0.0023; 16 weeks mild versus control: p = 0.0458; 16 weeks mild versus severe: p = 0.0003. ****p < 0.0001. B, Accelerated rotarod testing showing dynamic balance in mild mutants fails gradually between 8 and 23 weeks of age. Six weeks severe versus control: p = 0.0007; 8 weeks mild versus control: p = 0.0459; severe versus control: p = 0.0001; 10 weeks mild versus control: p = 0.0144; 16 weeks mild versus control: p = 0.0002; 23 weeks mild versus control: p = 0.0012; severe versus control: p = 0.0002. ****p < 0.0001. C, Mild mutants become unable to stand on their hind legs by 16 weeks. Data are mean ± SEM (severe mutants n = 5, mild mutants n = 3, control n = 9). Three weeks mild versus severe: p = 0.0006; mild versus control: p = 0.0055. ****p < 0.0001, two-way repeated-measures ANOVA with Bonferroni's multiple-comparisons test.