Figure 3. Drug response from pre to post treatment in drug-matched open-label and placebo-controlled trials.

There was a significant difference between study effect sizes between drug-matched open-label (k = 12), placebo-controlled drug (k = 12), and placebo-controlled placebo (k = 12) treatment groups. The overall effect was assessed using a univariate analysis of variance and Sidak correction for multiple comparisons was applied to the pairwise comparisons. *Significant at p < 0.01; **significant at p < 0.05.