Table 1.

Summary of X chromosome effects on adiposity in mouse and human models.

Model	This model tests:	Comparisons	Relative adiposity
FCG	Is XX different from XY?	XXF vs. XYF XXM vs. XYM	XXF > XYF XXM > XYM
XY*	Is difference caused by number of X or Y?	XX vs. XO XY vs. XXY XX vs. XXY	2 X (XX, XXY) > 1 X (XO, XY)
Sex Chrom Trisomy	Is difference caused by number of X or Y?	XY vs. XXY XY vs. XYY	2 X (XXY) > 1 X (XY) no effect of Y chrom number
Human Klinefelter syndrome (XXY)	Does X chrom dosage affect adiposity in humans?	XXY vs. XY	XXY > XY