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. Author manuscript; available in PMC: 2017 May 25.
Published in final edited form as: J Immunol. 2009 Sep 14;183(7):4809–4816. doi: 10.4049/jimmunol.0901616

FIGURE 5.

FIGURE 5

An increased frequency of GADp217-specific FoxP3-expressing Treg cells is detected in sIAg7-GADp217 vaccinated NOD mice. A, Representative FACS data of sIAg7-GADp217 multimer-binding CD4+ T cells ex vivo expressing FoxP3 and surface TGF-β1 from the islets of sIAg7-GADp217 and sIAg7-HEL-treated (Tx) NOD female mice. B, Frequency ± SD of sIAg7-GADp217 multimer-staining CD4+ T cells ex vivo expressing FoxP3 in the spleen, PLN, MLN, and islets of n = 5 individual NOD female mice treated with sIAg7-GADp217 and sIAg7-HEL. *, p ≤ 0.004 by Student’s t test, for sIAg7-GADp217 vs sIAg7-HEL dimer treated animals for a given tissue. p < 10−3 by one-way ANOVA test for sIAg7-GADp217 vs sIAg7-HEL treated NOD mice.