Table 1.

Maximum Treadmill Stepping Speed at Key Time Points

	Maximum treadmill speed
Cat	Post-injury pre-graft	3 Weeks post-graft	5 Weeks post-graft
ACUTE-1	N/A	0.3 m/sec	0.8 m/sec
ACUTE-2	N/A	0.8 m/sec	0.8 m/sec
SUB-CHRONIC-1	N/A	0.6 m/sec	0.8 m/sec
SUB-CHRONIC-2	N/A	-----	-----
SUB-CHRONIC-3	N/A	0.8 m/sec	0.8 m/sec
SUB-CHRONIC-4	N/A	0.8 m/sec	0.8 m/sec
SUB-CHRONIC-5	N/A	0.8 m/sec	0.8 m/sec
SUB-CHRONIC-6	No kinematics
CHRONIC-1	-----	0.6 m/sec	0.8 m/sec
CHRONIC-2	0.4 m/sec	0.8 m/sec	0.8 m/sec
CHRONIC-3	0.3 m/sec	0.7 m/sec	0.8 m/sec
CHRONIC-4	ND	ND	0.8 m/sec
CONTROL-1	ND	-----	0.4 m/sec
CONTROL-2	ND	0.4 m/sec	0.4 m/sec

Maximum treadmill walking speeds for cats in the study at the time points tested. Dashes (-) indicate an inability to perform 10 consecutive plantar weight-bearing steps at any speed, “ND” indicates that data was not collected for a time point, and “N/A” indicates that the time point is not applicable to a particular group. Only one neurotrophin treated cat (SUB-CHRONIC 2) was incapable of walking at any treadmill speed at any time point. Stepping ability of CHRONIC cats was recorded 1 week prior to grafting, to quantify any spontaneous recovery at 5 weeks post-transection. Minimal stepping ability was present at this time point, and only two cats were capable of any stepping at low treadmill speeds (≤0.4 m/sec) and with poor weight support. At 3 weeks post grafting, half of the CHRONIC cats recovered stepping at the maximum treadmill speed (0.8 m/sec), whereas the remaining half recovered some stepping at lower speeds. All graft cats except SUB-CHRONIC 2 were capable of full plantar weight- bearing stepping by 5 weeks after grafting at all tested treadmill speeds (0.3–0.8 m/sec). Recovery in the control cats was limited (low walking speeds and poor quality of stepping, with most steps taken on the dorsal aspect of the foot).