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To mimic convection enhanced delivery infusion times, DIPG cells were treated for two six hour periods with carboplatin followed by assessment of cell viability 72h later. DUB D003 is the most resistant to short term carboplatin exposure with an IC50 of 0.047mg/ml, followed by SF8628 with an IC50 of 0.026 mg/ml whilst SF7761 has an IC50 of 0.0048 mg/ml.
