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. 2017 May 25;12(5):e0176855. doi: 10.1371/journal.pone.0176855

Fig 5. Anti-tumour effect of carboplatin on DIPG cells pre-treated with sodium valproate.

Fig 5

DIPG cells were treated with valproate for 72 hours followed by two six hours carboplatin treatments and a final 72 hours of valproate. (A) Pre-treatment of SF7761, SF8628 and DUB D003 with sodium valproate followed by carboplatin, bars represent mean of at least three independent experiments, error bars indicate standard error. * p<0.05, assess by ANOVA. (B) To determine synergy, combination index (CI) values were calculated by CompuSyn software, and plotted against carboplatin dose using GraphPad Prism software. CI values below 1 (dotted line through y-axis), represent synergistic combinations.