Changes in (a) CRL5876 and (b) HTB177 cell viability, 48 h and seven days after irradiations with SOBP protons (1H) and carbon ions (12C), obtained with SRB assay. For CRL5876 cells, applied doses were 1, 2, 4, 6, and 8 Gy, while for HTB177 they were 0.5, 1, 2, 3, 4, and 5 Gy. Results are presented as mean ± standard error of mean (SEM).
+Statistical significance compared with the control, *Statistical significance SOBP protons versus carbon ions: +,*0.01 < P < 0.05; ++, **0.001< P < 0.01; +++,***P < 0.001