Figure 5.

Changes in p53 (a and b), p21 (c and d), γH2AX (e and f), BAX and Bcl-2 (g and h) levels in HTB177 cells. Dose-dependent changes were followed 2 h after irradiation with different doses (1 and 3 Gy) of SOBP protons and carbon ions. Dynamic changes in the level of proteins were analyzed after irradiations with 4 Gy with SOBP protons and carbon ions. Time points are 0.5, 2, 6, and 24 h. Results are presented as mean ± standard error of mean (SEM).

*Statistical significance SOBP compared with the control, ⁺Statistical significance carbon ions compared with the control, ^$ Statistical significance SOBP versus carbon ions: *,⁺,^$0.01 < P < 0.05; **,⁺⁺,^$$0.001 < P < 0.01; ***,⁺⁺⁺,^$$$P < 0.001