Figure 5.

mTOR abolished the effects of BCAR4 knockdown on chondrosarcoma cell proliferation and migration. (a) Relative cell viability and (b) migration were measured in SW1353 cells transfected with si-BCAR4 or NC or si-BCAR4 and pcDNA or si-BCAR4 and pcDNA-mTOR. **P < 0.001 vs. si-NC, ^##P < 0.001 vs. si-BCAR4 + pcDNA. (c) Relative cell viability and (d) migration were measured in HCS-2/8 cells treated with pcDNA or pcDNA-BCAR4 or pcDNA-BCAR4 and DMSO or pcDNA-BCAR4 and Rapamycin. **P < 0.001 vs. pcDNA, ^##P < 0.001 vs. pcDNA-BCAR4 + DMSO