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. 2017 May 25;12(5):e0177770. doi: 10.1371/journal.pone.0177770

Table 1. Key assumptions used in the model.

Assumption Details
ARVs included Basis MPP’s Priority Document (details in Table 2)
Timeline 2012–2028
Duration of Impact Based on projected start—date of impact and expiry date of blocking patents
PLHIVs on treatment Based on UNAIDS Fast track report [3,4]
ARV Market share Based on forecasts carried out by the MPP in collaboration with the WHO from 2015 to 2025 [14]
Countries included Low and Middle income countries as per World Bank
Number of countries impacted by licences Impact of MPP was attributed to only those countries where the licence had unblocked an existing patent
Baseline Price Based on originator tiered pricing as per Untangling the Web of Price Reductions by MSF
Impacted Price Applied an international industry historic average of year-over-year erosion rates of generic product prices
Royalty saving Basis royalty rates in agreements before and after the MPP licence
Net present value Discounting factor of 3.5% used to obtain Net Present Value
Probability Factor Based on the level of negotiations
Market Assumptions No change in economic environment
MPP Operating Cost Actual expenses and grant received till date. For years 2021–2028, projected costs are associated only with the management of medicine development projects for ARVs licensed by MPP