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. 2017 May 25;12(5):e0178215. doi: 10.1371/journal.pone.0178215

Fig 7. High glucose induced mitochondrion mediated apoptosis and anti-apoptosis effects of ADPN.

Fig 7

Intermittent and stable high glucose can upregulate the protein P53, Bax. Both the intermittent and stable high glucose can downregulate the Bcl-2 protein. Both intermittent and stable high glucose induced the resealed of cytochrome C, actived the caspase 3 and caspase 9, whit the increase expression of cleaved caspase3 and caspase 9. After treated with ADPN, we found that the P53, Bax were downregulated, and the Bcl-2 was downregulated than the group without ADPN. And, after the cell treated with ADPN, the release of cytochrome C, the activation of caspase 3, caspase 9 were all inhibited.