Table 3. Putative miR-204 gene targets selected according to the criteria described in the text.
GENE/miR204 GC | GENE/miR204 TGCA GC | GENE\miR204 TCGA CCA | |||||
---|---|---|---|---|---|---|---|
GENE | n° prediction tool | R Pearson | p value | R Pearson | p value | R Pearson | p value |
RCC2 | 4 | −0,9259432 | 4,8531E-09 | −0,39189627 | 2,0096E-11 | −0,37019042 | 0,01231233 |
STIL | 4 | −0,90967035 | 2,72938E-08 | −0,44694006 | 1,14003E-14 | −0,38264482 | 0,00948156 |
MKI67 | 4 | −0,90660095 | 3,64488E-08 | −0,36256828 | 6,35967E-10 | −0,50656626 | 0,00038426 |
ARHGAP11A | 5 | −0,89475864 | 1,02086E-07 | −0,40569912 | 3,49858E-12 | −0,42570867 | 0,00355126 |
RAD51 | 5 | −0,89072633 | 1,41036E-07 | −0,31617519 | 7,6835E-08 | −0,43233349 | 0,00301837 |
CDCA8 | 4 | −0,88927317 | 1,57974E-07 | −0,28193562 | 1,62836E-06 | −0,49308009 | 0,00057882 |
SHCBP1 | 5 | −0,88424802 | 2,31111E-07 | −0,24936578 | 2,08907E-05 | −0,47218798 | 0,00105717 |
KIF15 | 5 | −0,88160634 | 2,80337E-07 | −0,38587499 | 4,20188E-11 | −0,42592368 | 0,00353275 |
FOXM1 | 4 | −0,86068505 | 1,11981E-06 | −0,28869853 | 9,18839E-07 | −0,52210414 | 0,00023458 |
CENPE | 5 | −0,86029691 | 1,1465E-06 | −0,36510107 | 4,78314E-10 | −0,45798201 | 0,00155894 |
CENPA | 5 | −0,85914302 | 1,22917E-06 | −0,29483137 | 5,39816E-07 | −0,50666915 | 0,00038304 |
NOTCH1 | 6 | −0,84324211 | 3,02813E-06 | −0,28549794 | 1,20686E-06 | −0,21394612 | 0,15818325 |
RACGAP1 | 4 | −0,84295458 | 3,07508E-06 | −0,3469437 | 3,49224E-09 | −0,50154541 | 0,00044846 |
CCNF | 5 | −0,83267343 | 5,22975E-06 | −0,30009111 | 3,38701E-07 | −0,4391877 | 0,00254234 |
PDGFRB | 5 | −0,82538503 | 7,46221E-06 | −0,21481712 | 0,000219939 | −0,14263023 | 0,34996411 |
CDC25B | 6 | −0,81115812 | 1,42879E-05 | −0,28939643 | 8,65415E-07 | −0,39632472 | 0,00703537 |
SLC27A2 | 6 | −0,80642962 | 1,75228E-05 | −0,28327399 | 1,45574E-06 | 0,167963321 | 0,27007769 |
EPHB2 | 6 | −0,8036086 | 1,97406E-05 | −0,28920466 | 8,79792E-07 | −0,26614462 | 0,07720508 |
FLVCR2 | 5 | −0,80297101 | 2,02742E-05 | −0,0582144 | 0,17304948 | 0,135952614 | 0,37320902 |
PAICS | 4 | −0,79451311 | 2,8629E-05 | −0,32532083 | 3,17611E-08 | 0,038792834 | 0,80026628 |
MSR1 | 5 | −0,78443992 | 4,23269E-05 | −0,28314372 | 1,47174E-06 | −0,02154619 | 0,88827667 |
PLXNA1 | 4 | −0,78286517 | 4,49122E-05 | −0,31782911 | 6,56325E-08 | −0,32716505 | 0,02825738 |
CDH13 | 4 | −0,78204978 | 4,63035E-05 | −0,28911799 | 8,86364E-07 | −0,26173396 | 0,08242663 |
CLDN1 | 5 | −0,77870607 | 5,24052E-05 | −0,34912016 | 2,76994E-09 | −0,23370431 | 0,12232108 |
HSPH1 | 7 | −0,770814 | 6,96208E-05 | −0,26576022 | 6,02835E-06 | −0,04712768 | 0,75852626 |
SCD | 5 | −0,76457661 | 8,64784E-05 | −0,15310422 | 0,006377357 | 0,194194475 | 0,20116229 |
RTKN2 | 7 | −0,76044893 | 9,94697E-05 | −0,20430407 | 0,000420274 | −0,3266414 | 0,0285259 |
LOXL2 | 5 | −0,75798142 | 0,00010801 | −0,19661312 | 0,000661776 | −0,38198982 | 0,00961508 |
CACYBP | 5 | −0,75630081 | 0,000114181 | −0,39534122 | 1,30887E-11 | −0,39391464 | 0,00742171 |
MMP3 | 5 | −0,75226712 | 0,000130239 | −0,16531766 | 0,003552365 | NA | NA |
KIAA1199 | 4 | −0,74112207 | 0,000185051 | −0,17897512 | 0,001762564 | −0,23281225 | 0,12379495 |
F2R | 5 | −0,73972529 | 0,000193143 | −0,19232703 | 0,000846249 | −0,07661501 | 0,61691822 |
INHBA | 7 | −0,73433465 | 0,000227276 | −0,27265961 | 3,48467E-06 | −0,18796101 | 0,21628935 |
MANEAL | 4 | −0,7321102 | 0,000242795 | −0,23681267 | 5,11871E-05 | 0,036703909 | 0,81081924 |
PKM2 | 4 | −0,72843075 | 0,000270451 | −0,21819256 | 0,000177462 | −0,45360692 | 0,00175125 |
TFAP2A | 4 | −0,71306986 | 0,000416889 | −0,24246373 | 3,43952E-05 | −0,48946511 | 0,00064417 |
FAP | 7 | −0,71170461 | 0,000432668 | −0,20515966 | 0,000399165 | −0,2879022 | 0,0551385 |
For each gene are reported the number of the microRNA target prediction tools used for the analysis, and the Pearson anti-Correlation value and the p-value calculated for our discovery set, for the gastric TGCA dataset, and the cholangiocarcinoma TGCA dataset, respectively.