Figure 7. Enhanced IFN-γ activity leads to dysregulated hematopoiesis in Il2^−/− mice.

A. Distribution of LSK cells in BM from WT, Il2^−/−, Ifng^−/− and Il2^−/−Ifng^−/− mice. B. Quantification of BM LSK cells in Il2^−/−Ifng^−/− mice compared to WT, Il2^−/−and Ifng^−/− mice. C. Distribution of BM cells in indicated mice according to their FSC and SSC pattern. D. Evaluation of c-Kit⁺ and Sca1⁺ cells distribution among lineage-negative BM cells in Il2^−/−Ifng^−/− mice compared to littermate control mice. E. FSC and SSC patterns of Il2^−/−Ifng^−/− LSK cells compared to that of WT, Il2^−/− and Ifng^−/− cells. F. FSC and SSC patterns of Il2^−/−Bim^−/− LSK cells compared to that of WT, Il2^−/− and Bim^−/− cells. G. Body weight, H. spleen weight, and I. splenocytes number in Il2^−/−Ifng^−/− mice compared to WT, Il2^−/−and Ifng^−/− mice. J. Survival curve for Il2^−/−Ifng^−/− mice compared to WT, Il2^−/−and Ifng^−/− mice. K. Profile of Il2^−/−Ifng^−/− BM CD4⁺ T cells according to their FSC and SSC distribution pattern compared to that of littermate control mice. L. FSC and SSC distribution of Il2^−/−Bim^−/− BM CD4⁺ T cells compared to that of littermate control mice. M. Profile of Il2^−/−Il7ra^−/− BM CD4⁺ T cells according to their FSC and SSC distribution pattern compared to that of WT, Il2^−/−and Il7ra^−/− mice. Numbers inside each dot plot represent percent respective population and in histograms represent the MFI. Data are representative of 3 independent experiments, (n = 3 per group) and shown as mean ± s.d., in B, D, G, H & I ***P < 0.0001, ns = not significant, one-way ANOVA.